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Amino Acid Metabolism - Medical Science

Q1:

A person with phenylketonuria is advised not to consume which of the following products?

A Glycine containing foods

B Fat containing food

C Glucose

D Aspartame

ANS:D - Aspartame

Aspartame is a methyl ester of the aspartic acid/phenylalanine dipeptide.

Hydrolysis of aspartame produces phenylalanine in the body.

Phenylketonurics have deficient phenylalanine hydroxylase required for the metabolism of phenylalanine, thus phenylalanine accumulation takes place and produces toxic products like phenylpyruvate via transamination.