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Microorganisms and Disease

Q1: Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

A ADP ribosylation of adenylate cyclase that stops production of cAMP

B ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP

C cleavage of rRNA that results in disruption of ribosome function

D ADP ribosylation of guanylate cyclase that stimulates production of cGMP

ANS:B - ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP

Overproduce cAMP, which disrupts the fluid and electrolyte balance, causing hyper secretion of chloride and bicarbonate.



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