Glycolysis - Medical Science

Q1:

Glycolytic pathway regulation involves

A allosteric stimulation by ADP

B allosteric inhibition by ATP

C feedback, or product, inhibition by ATP

D all of the above

ANS:D - all of the above

Phospho kinase 1 enzyme has about 4 active sites i.e active site for ATP, Citrate, AMP & Fructose 2-6 Bisphosphate site, Increase in Fructose 2-6 Bisphosphate (a very powerful stimulant of Phospho Kinase 1).

ATP & Citrate, signals Phospho Kinase 1 to Phosphorylate more Fructose 6 phosphate into Fructose 1-6 bisphosphate. In my opinion this is the Enzymatic Allosteric Regulation.