Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are-A-copies of the gene with an altered sequence so that a restriction site is insertedB-mutagenized copies of a geneC-short sequences that will hybridize only to a specific base sequenceD-PCR amplified variable numbers of tandem repeats (VNTRs)-C-short sequences that will hybridize only to a specific base sequence

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Recombinant DNA Technology

Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are

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Recombinant DNA Technology

Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are

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