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Microorganisms and Disease

Q1: The "A" subunit of diphtheria toxin

A binds host cell receptors found on heart cells

B cause ADP ribosylation of a factor involved in protein synthesis

C forms cAMP that leads to fluid accumulation

D lysis macrophages with the release of cytokines

ANS:B - cause ADP ribosylation of a factor involved in protein synthesis

Corynebacterium diphtheria _ a Gram Positive, club-shaped rod often occurring in V-and L-shaped arrangements ("Chinese characters"). Human respiratory bacterium.

Single potent exotoxin damages the pharyngeal mucosal and also circulates in the blood. The toxin is only produced by the strains of C. Diphtheriae that are lysogenized by bacteriophage carrying the tox positive gene.

Diphtheria toxin is a potent ADP ribosyl transferase that ADP-ribosylates EF-2 shutting down Eukaryota protein synthesis in mucosa, heart, and nerves.



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