Q1: Which of the following could act as an uncoupler of electron transport and ATP synthesis?

A Both (a) and (b)

B The Fo base-piece of ATP synthase (without the Fl subunit)

C neither (a) nor (b)

D Dinitrophenol

ANS:D - Both (a) and (b)

Uncouplers of oxidative phosphorylation in the mitochondria inhibit the coupling between the electron transport and phosphorylation reactions thus inhibit ATP Synthesis without affecting the respiratory chain and ATP synthase. 2, 4 DNP and so base are uncouplers.

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