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Enzymes and Kinetics - Medical Science

Q1:

The rate-determining step of Michaelis Menten kinetics is

A the complex formation step

B the complex dissociation step to produce product

C the product formation step

D Both (a)and(c)

ANS:B - the complex dissociation step to produce product

It is always assumed that the rate of formation and dissociation of the enzyme-substrate complex is the same but the fact is that the formation rate is always greater than the dissociation rate* km always greater than kd.

Therefore, it is written to say that the dissociation rate does determine the rate.